Drug Alert – Diphenoxyliate HCL – 2025/01/28

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What is it?

An opioid anti-diarrhea drug is used along with other treatments such as fluid and electrolyte replacement for the treatment of diarrhea.

How is it sold?

Brown Down

What are the risks?

Overdose and/or death

Side effects

  • Nausea
  • Vomiting
  • Loss of appetite
  • Headache
  • Restlessness
  • Fatigue
  • Confusion or changes in mood

What does an overdose look like?

  • Severe drowsiness
  • Shortness of breath or troubled breathing
  • Fast heartbeat
  • Unusual warmth, dryness, and flushing of the skin

Ways to stay safe

  • Try not to use it alone
    • Buddy up with someone you trust.
    • Don’t use it at the same time. Make sure the other person is okay before you use it.
  • Carry Naloxone and know how to use it
    • Visit Northwestern Health Unit for a kit and a refresher on how to save a life.
    • If you think someone is overdosing, give Naloxone!
  • If you must use it alone, have a safety plan
    • Get someone to check on you in person or by phone.
    • Download the lifeguard app – it could save your life!
    • Call NORS before you use 1-888-688-NORS (6677).
  • See a health care provider if:
    • If you have a wound – left untreated, it could lead to amputation.
    • You need to talk about an overdose or other experience.
    • You need other health care.

Additional information

Confirmed in Winnipeg, MB. Alert issued due to proximity, no reported toxicity at the local level to date.

Call Northwestern Health Unit (NWHU) for more information:

75 Van Horne Ave, Dryden, ON
Phone: 807-223-8777
Cell Phone: 807-220-0626

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